Brittle Bone Brothers: Osteogenesis Imperfecta Conventional Serial Case

Osteogenesis Imperfecta is a hereditary connective tissue disorder due to COL1A1/2 mutation causing gene defect encoding proteins metabolize collagen. The skeletal manifestation of OI bone incompetence, hence the name brittle disease. Here we report three cases type IV in adults. Skeletal conventional X-rays were performed all patients and them has similar results such as bowing deformities long bones, old union some non-union fractures with extreme angulation severe osteoporosis. are classified based on structure, sclera colorization, dentinogenesis, functional metabolic genetically. I can live until adults; also, same be found siblings. solely make diagnosis.